USAGE OF " IN SPITE & DESPITE"

There have been lots of doubts about the usage of the words in spite of and despite. besides the native speakers of english the other growing population who are trying to be fluent in english since it has been commented as the major communicative business language and there is no explanation needed why people around the globe are trying to excel themselves in the language.

let us now see the usage of the words in spite and despite which are of one of the major things which is creating chaos among the learners.

usually in spite should be mentioned in two words and not as inspite.
in spite should be followed by of and is mandatory in the grammar followed.

despite can be used as an alternative for in spite of and the thing to be noticed is it should not be followed by of.
eg : in spite of illness he managed to pass the examination.
despite illness he managed to pass the examination